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Issue 15, 2012

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

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Abstract

We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1–42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2–4 GPa.

Graphical abstract: Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

Article information


Submitted
30 Mar 2012
Accepted
09 May 2012
First published
11 May 2012

Nanoscale, 2012,4, 4426-4429
Article type
Communication

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

J. Adamcik, C. Lara, I. Usov, J. S. Jeong, F. S. Ruggeri, G. Dietler, H. A. Lashuel, I. W. Hamley and R. Mezzenga, Nanoscale, 2012, 4, 4426 DOI: 10.1039/C2NR30768E

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