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Issue 13, 2012
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Graphene oxide–Fe3O4 magnetic nanocomposites with peroxidase-like activity for colorimetric detection of glucose

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Abstract

In this report, graphene oxide–Fe3O4 magnetic nanocomposites were demonstrated to possess intrinsic peroxidase-like activity and enhanced affinity toward H2O2. The nanocomposites retain their magnetic properties and can be effectively separated by a magnet. Significantly, they were proved to be novel peroxidase mimetics which could quickly catalyze oxidation of the peroxidase substrate 3,3,5,5-tetramethylbenzidine (TMB) in the presence of H2O2, producing a blue-colored solution. Kinetic analysis indicates that the catalytic behavior is in accord with typical Michaelis–Menten kinetics and follows a ping-pong mechanism. On the basis of the high activity, the reaction provides a simple, sensitive and selective method for colorimetric detection of glucose in diabetic urine.

Graphical abstract: Graphene oxide–Fe3O4 magnetic nanocomposites with peroxidase-like activity for colorimetric detection of glucose

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Article information


Submitted
28 Dec 2011
Accepted
17 Apr 2012
First published
23 Apr 2012

Nanoscale, 2012,4, 3969-3976
Article type
Paper

Graphene oxide–Fe3O4 magnetic nanocomposites with peroxidase-like activity for colorimetric detection of glucose

Y. Dong, H. Zhang, Z. U. Rahman, L. Su, X. Chen, J. Hu and X. Chen, Nanoscale, 2012, 4, 3969
DOI: 10.1039/C2NR12109C

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