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Issue 1, 2012
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SERS assisted ultra-fast peptidic screening: a new tool for drug discovery

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Abstract

Herein we present a direct label-free ultra-fast method for the identification and classification of the active members of a combinatorial library directly on the solid support used for their synthesis. The method is based on the appropriate functionalization of polyethylene glycol grafted polystyrene (TentaGel®) microbeads with Au@Ag nanoparticles, the use of these materials directly as solid-phase supports for the synthesis of combinatorial libraries of peptides and the subsequent SERS analysis for identification of each peptide on each bead.

Graphical abstract: SERS assisted ultra-fast peptidic screening: a new tool for drug discovery

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Supplementary files

Article information


Submitted
13 Sep 2011
Accepted
04 Oct 2011
First published
09 Nov 2011

Nanoscale, 2012,4, 113-116
Article type
Communication

SERS assisted ultra-fast peptidic screening: a new tool for drug discovery

R. Pérez-Pineiro, M. A. Correa-Duarte, V. Salgueirino and R. A. Alvarez-Puebla, Nanoscale, 2012, 4, 113
DOI: 10.1039/C1NR11293G

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