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Abstract | Cited by

Covering: 1972 to 2011

Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure–activity relationships, pharmacology, and clinical development of triptolide in the last forty years.

Graphical abstract: Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

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