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Issue 2, 2012
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Synthesis and fluorescent properties of cationic carbosilane dendrimers containing eugenol linkers for their use in biomedical applications

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Abstract

A synthetic strategy has been carried out to prepare a new family of dendrimers containing eugenol linkers between the carbosilane scaffold and the peripheral amine or ammonium groups, of type Gn-[Si(CH2)3C6H3(OMe){O(CH2)2NMe2}]m or Gn-[Si(CH2)3C6H3(OMe){O(CH2)2NMe3+I}]m respectively. Cationic carbosilane dendrimers have shown fluorescent properties due to the presence of the aromatic rings. A preliminary study of the interaction of dendrimers with two model drugs as examples of Active Pharmaceutical Ingredients (APIs) has been performed by fluorescence and NMR methods. This study determines the ability of these dendrimers to interact with potassium phenoxymethylpenicillin (Penicillin VK) as an example of an anionic low molecular weight drug entity or bovine serum albumin (BSA) as a biopharmaceutical drug protein entity, affording an appropriate dendritic system for its use in certain biological applications like drug delivery.

Graphical abstract: Synthesis and fluorescent properties of cationic carbosilane dendrimers containing eugenol linkers for their use in biomedical applications

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Publication details

The article was received on 28 Apr 2011, accepted on 14 Jun 2011 and first published on 07 Jul 2011


Article type: Paper
DOI: 10.1039/C1NJ20374F
New J. Chem., 2012,36, 360-370

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    Synthesis and fluorescent properties of cationic carbosilane dendrimers containing eugenol linkers for their use in biomedical applications

    B. Rasines, J. Sánchez-Nieves, I. T. Molina, M. Guzmán, M. xmlns="http://www.rsc.org/schema/rscart38"> <. Á. Muñoz-Fernández, R. Gómez and F. J. de la Mata, New J. Chem., 2012, 36, 360
    DOI: 10.1039/C1NJ20374F

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