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Issue 5, 2013
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Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis

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Abstract

Monocyte chemoattractant protein (CCL2) plays a major role in the recruitment of monocytes during inflammation. In this study we analysed properties of synthetic CCL2 inhibitors in inhibiting CCL2 mediated monocyte migration. Using trans-endothelial chemotaxis assays compounds C1 and C5 were found to significantly reduce CCL2 mediated migration. Flow based adhesion assays showed reduction in adhesion to VCAM-1 in the presence of 10 nM CCL2 and 50 μM C5 (p < 0.05). Further studies with these compounds can aid in their development as anti-inflammatory therapies.

Graphical abstract: Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis

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Publication details

The article was received on 08 Feb 2013, accepted on 31 Mar 2013 and first published on 02 Apr 2013


Article type: Concise Article
DOI: 10.1039/C3MD00043E
Med. Chem. Commun., 2013,4, 860-864

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    Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis

    M. Saleki, N. Colgin, J. A. Kirby, S. L. Cobb and S. Ali, Med. Chem. Commun., 2013, 4, 860
    DOI: 10.1039/C3MD00043E

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