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Issue 2, 2013
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Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

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Abstract

Novel guanidinium and urea derivatives of 1-deoxynojirimycin were prepared using a concise synthetic protocol and tested against a panel of glycosidases for their inhibitory properties. Potent and selective inhibition was observed with both classes of compounds. Further investigation involving an expanded series of NG-substituted guanidinium deoxynojirimycin analogues revealed distinct inhibitory profiles in the inhibition of the glycosidases tested.

Graphical abstract: Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

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Supplementary files

Article information


Submitted
10 Nov 2012
Accepted
29 Nov 2012
First published
30 Nov 2012

Med. Chem. Commun., 2013,4, 387-393
Article type
Concise Article

Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

R. Kooij, H. M. Branderhorst, S. Bonte, S. Wieclawska, N. I. Martin and R. J. Pieters, Med. Chem. Commun., 2013, 4, 387
DOI: 10.1039/C2MD20343J

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