Novel aspects in structure–activity relationships of profiled 1-aza-9-oxafluorenes as inhibitors of Alzheimer's disease-relevant kinases cdk1, cdk5 and gsk3β†
Abstract
A novel series of derivatized 1-aza-9-oxafluorenes has been synthesized. Structure-directed substituents have been introduced and their effect on the inhibition of Alzheimer's disease-relevant kinases has been determined in in vitro assays. Novel structure–activity relationships were found depending on the varying substituents. Nanomolar