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Issue 1, 2013
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Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

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Abstract

Sulforaphane and erucin, two natural isothiocyanates that are highly abundant in broccoli and other cruciferous vegetables, were found to strongly inhibit quorum sensing and virulence in Pseudomonas aeruginosa. Mechanistic evaluations of these effects suggest that these isothiocyanates are antagonists of the transcriptional activator LasR.

Graphical abstract: Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

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Article information


Submitted
16 Jul 2012
Accepted
29 Aug 2012
First published
31 Aug 2012

Med. Chem. Commun., 2013,4, 175-179
Article type
Concise Article

Sulforaphane and erucin, natural isothiocyanates from broccoli, inhibit bacterial quorum sensing

H. Ganin, J. Rayo, N. Amara, N. Levy, P. Krief and M. M. Meijler, Med. Chem. Commun., 2013, 4, 175
DOI: 10.1039/C2MD20196H

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