Identification of a novel nanomolar inhibitor of hIcmt via a carboxylate replacement approach†
Abstract
A substrate-based approach to human isoprenylcysteine carboxyl methyltransferase (hIcmt)
* Corresponding authors
a
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA
E-mail:
rgibbs@purdue.edu
b
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
E-mail:
hrycyna@purdue.edu
c The Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA
A substrate-based approach to human isoprenylcysteine carboxyl methyltransferase (hIcmt)
J. D. Majmudar, A. Morrison-Logue, J. Song, C. A. Hrycyna and R. A. Gibbs, Med. Chem. Commun., 2012, 3, 1125 DOI: 10.1039/C2MD20108A
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