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Issue 8, 2012
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Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether

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Abstract

Helicobacter pylori affects a significant proportion of the human population. It is the primary agent responsible for gastric and duodenal ulcers and has been further linked with gastric cancer and mucosa-associated lymphoid tissue (MALT lymphoma). Eradication of H. pylori can cure these diseases; however the current therapies used are far from ideal. (+)-Spirolaxine methyl ether (2) exhibits potent activity against H. pylori and is therefore a promising drug candidate. Herein we report the synthesis of eight analogues of spirolaxine methyl ether (2), as well as their anti-H. pylori activity.

Graphical abstract: Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether

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Publication details

The article was received on 22 Dec 2011, accepted on 04 Jan 2012 and first published on 24 Jan 2012


Article type: Concise Article
DOI: 10.1039/C2MD00314G
Med. Chem. Commun., 2012,3, 938-943

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    Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether

    I. Dimitrov, D. P. Furkert, J. D. Fraser, F. J. Radcliff, O. Finch and M. A. Brimble, Med. Chem. Commun., 2012, 3, 938
    DOI: 10.1039/C2MD00314G

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