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Issue 8, 2012
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Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether

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Abstract

Helicobacter pylori affects a significant proportion of the human population. It is the primary agent responsible for gastric and duodenal ulcers and has been further linked with gastric cancer and mucosa-associated lymphoid tissue (MALT lymphoma). Eradication of H. pylori can cure these diseases; however the current therapies used are far from ideal. (+)-Spirolaxine methyl ether (2) exhibits potent activity against H. pylori and is therefore a promising drug candidate. Herein we report the synthesis of eight analogues of spirolaxine methyl ether (2), as well as their anti-H. pylori activity.

Graphical abstract: Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether

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Supplementary files

Article information


Submitted
22 Dec 2011
Accepted
04 Jan 2012
First published
24 Jan 2012

Med. Chem. Commun., 2012,3, 938-943
Article type
Concise Article

Synthesis and anti-Helicobacter pylori activity of analogues of spirolaxine methyl ether

I. Dimitrov, D. P. Furkert, J. D. Fraser, F. J. Radcliff, O. Finch and M. A. Brimble, Med. Chem. Commun., 2012, 3, 938
DOI: 10.1039/C2MD00314G

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