Issue 4, 2012
From the journal:

MedChemComm

Development of novel ionic liquids based on ampicillin†

Ricardo Ferraz,ab   Luís C. Branco,*a   Isabel M. Marrucho,*c   João M. M. Araújo,c   Luis Paulo N. Rebelo,c   Manuel Nunes da Ponte,a   Cristina Prudêncio,ad   João Paulo Noronhaa  and  Željko Petrovski*a  

* Corresponding authors

a Departamento de Química, REQUIMTE-CQFB, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
E-mail: z.petrovski@fct.unl.pt, l.branco@fct.unl.pt, imarrucho@itqb.unl.pt
Fax: +351 21 294 85 50

b Ciências Químicas e das Biomoléculas, Escola Superior de Tecnologia da Saúde do Porto do Instituto Politécnico do Porto, Portugal

c Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Apartado 127, 2780-157 Oeiras, Portugal
Web: www.itqb.unl.pt

d Centro de Farmacologia e Biopatologia Química (U38-FCT), Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Abstract

Novel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.

Graphical abstract: Development of novel ionic liquids based on ampicillin

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Article information

DOI
https://doi.org/10.1039/C2MD00269H
Article type
Concise Article
Submitted
24 Oct 2011
Accepted
13 Feb 2012
First published
15 Feb 2012

Med. Chem. Commun., 2012,3, 494-497

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Development of novel ionic liquids based on ampicillin

R. Ferraz, L. C. Branco, I. M. Marrucho, J. M. M. Araújo, L. P. N. Rebelo, M. N. da Ponte, C. Prudêncio, J. P. Noronha and Ž. Petrovski, Med. Chem. Commun., 2012, 3, 494 DOI: 10.1039/C2MD00269H

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