Issue 4, 2012

Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

Abstract

Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however threatening to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6′-N-acetyltransferase (AAC(6′)).

Graphical abstract: Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

Article information

Article type
Review Article
Submitted
06 Oct 2011
Accepted
20 Nov 2011
First published
22 Nov 2011

Med. Chem. Commun., 2012,3, 397-407

Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

K. Vong and K. Auclair, Med. Chem. Commun., 2012, 3, 397 DOI: 10.1039/C2MD00253A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements