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Issue 1, 2012
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Selective inhibition of E. coli1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates

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Abstract

DXP synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate, an essential precursor in pathogen isoprenoid biosynthesis. The selective inhibition of this ThDP-dependent transformation is a challenging goal in the development of isoprenoid biosynthesis inhibitors. Potent, selective inhibitors could lead to new anti-infective agents. Here, we demonstrate selective inhibition of E. coliDXP synthase by butylacetylphosphonate.

Graphical abstract: Selective inhibition of E. coli1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

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Publication details

The article was received on 13 Sep 2011, accepted on 19 Sep 2011 and first published on 26 Oct 2011


Article type: Concise Article
DOI: 10.1039/C1MD00233C
Citation: Med. Chem. Commun., 2012,3, 65-67
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    Selective inhibition of E. coli1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates

    J. M. Smith, R. J. Vierling and C. F. Meyers, Med. Chem. Commun., 2012, 3, 65
    DOI: 10.1039/C1MD00233C

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