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Issue 3, 2013
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Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

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Abstract

Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results.

Graphical abstract: Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

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Publication details

The article was received on 11 Oct 2012, accepted on 25 Oct 2012 and first published on 26 Oct 2012


Article type: Paper
DOI: 10.1039/C2LC41144J
Citation: Lab Chip, 2013,13, 386-390
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    Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

    C. Parolo, M. Medina-Sánchez, A. de la Escosura-Muñiz and A. Merkoçi, Lab Chip, 2013, 13, 386
    DOI: 10.1039/C2LC41144J

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