Issue 24, 2012
From the journal:

Lab on a Chip

DropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications†

Erica Ueda,a   Florian L. Geyer,ab   Victoria Nedashkivskaab  and  Pavel A. Levkin*ab  

* Corresponding authors

a Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
E-mail: levkin@kit.edu
Fax: +49 721608 29040
Tel: +49 721608 29175

b Department of Applied Physical Chemistry, Heidelberg University, 69047 Heidelberg, Germany

Abstract

We describe a one-step method for creating thousands of isolated pico- to microliter-sized droplets with defined geometry and volume. Arrays of droplets are instantly formed as liquid moves along a superhydrophilic–superhydrophobic patterned surface. Bioactive molecules, nonadherent cells, or microorganisms can be trapped in the fully isolated microdroplets for high-throughput screening, or in hydrogel micropads for screening in 3D microenvironments.

Graphical abstract: DropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications

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Article information

DOI
https://doi.org/10.1039/C2LC40921F
Article type
Paper
Submitted
14 Aug 2012
Accepted
11 Oct 2012
First published
12 Oct 2012

Lab Chip, 2012,12, 5218-5224

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DropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications

E. Ueda, F. L. Geyer, V. Nedashkivska and P. A. Levkin, Lab Chip, 2012, 12, 5218 DOI: 10.1039/C2LC40921F

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