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Issue 21, 2012
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A magnetic cell-based sensor

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Abstract

Cell-based sensing represents a new paradigm for performing direct and accurate detection of cell- or tissue-specific responses by incorporating living cells or tissues as an integral part of a sensor. Here we report a new magnetic cell-based sensing platform by combining magnetic sensors implemented in the complementary metal-oxide-semiconductor (CMOS) integrated microelectronics process with cardiac progenitor cells that are differentiated directly on-chip. We show that the pulsatile movements of on-chip cardiac progenitor cells can be monitored in a real-time manner. Our work provides a new low-cost approach to enable high-throughput screening systems as used in drug development and hand-held devices for point-of-care (PoC) biomedical diagnostic applications.

Graphical abstract: A magnetic cell-based sensor

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Publication details

The article was received on 23 Apr 2012, accepted on 13 Aug 2012 and first published on 14 Aug 2012


Article type: Paper
DOI: 10.1039/C2LC40392G
Lab Chip, 2012,12, 4465-4471

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    A magnetic cell-based sensor

    H. Wang, A. Mahdavi, D. A. Tirrell and A. Hajimiri, Lab Chip, 2012, 12, 4465
    DOI: 10.1039/C2LC40392G

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