Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 16, 2012
Previous Article Next Article

Force driven separation of drops by deterministic lateral displacement

Author affiliations

Abstract

We investigate the separation of drops in force-driven deterministic lateral displacement (f-DLD), a promising high-throughput continuous separation method in microfluidics. We perform scaled-up macroscopic experiments in which drops settle through a square array of cylindrical obstacles. These experiments demonstrate the separation capabilities—and provide insight for the design—of f-DLD for drops of multiple sizes, including drops that are larger than the gaps between cylinders and exhibit substantial deformation as they move through the array. We show that for any orientation of the driving force relative to the array of obstacles, the trajectories of the drops follow selected locking directions in the lattice. We also found that a simple collision model accurately describes the average migration angles of the drops for the entire range of sizes investigated here, and for all forcing directions. In addition, we found a difference of approximately 20° between the critical angles at which the smallest and largest drops first move across a line of obstacles (column) in the array, a promising result in terms of potential size resolution of this method. Finally, we demonstrate that a single line of cylindrical obstacles rotated with respect to the driving force is capable of performing binary separations. The critical angles obtained in such single line experiments, moreover, agree with those obtained using the full array, thus validating the assumption in which the trajectory (and average migration angle) of the drops is calculated from individual obstacle-drop collisions.

Graphical abstract: Force driven separation of drops by deterministic lateral displacement

Back to tab navigation

Article information


Submitted
06 Mar 2012
Accepted
18 Apr 2012
First published
19 Apr 2012

Lab Chip, 2012,12, 2903-2908
Article type
Paper

Force driven separation of drops by deterministic lateral displacement

T. Bowman, J. Frechette and G. Drazer, Lab Chip, 2012, 12, 2903
DOI: 10.1039/C2LC40234C

Social activity

Search articles by author

Spotlight

Advertisements