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Issue 5, 2012
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Applying microdroplets as sensors for label-free detection of chemical reactions

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Abstract

Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quantitative and label-free marker for reactions inside the droplets. We present an analysis of the underlying mechanism and apply the method for monitoring metabolic activity at a single-cell level.

Graphical abstract: Applying microdroplets as sensors for label-free detection of chemical reactions

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Article information


Submitted
08 Oct 2011
Accepted
05 Dec 2011
First published
17 Jan 2012

Lab Chip, 2012,12, 916-922
Article type
Paper

Applying microdroplets as sensors for label-free detection of chemical reactions

T. W. Hofmann, S. Hänselmann, J. Janiesch, A. Rademacher and C. H. J. Böhm, Lab Chip, 2012, 12, 916
DOI: 10.1039/C2LC20971C

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