Jump to main content
Jump to site search

Issue 1, 2012
Previous Article Next Article

Flexible microfluidic cloth-based analytical devices using a low-cost wax patterning technique

Author affiliations

Abstract

This paper describes the fabrication of microfluidic cloth-based analytical devices (μCADs) using a simple wax patterning method on cotton cloth for performing colorimetric bioassays. Commercial cotton cloth fabric is proposed as a new inexpensive, lightweight, and flexible platform for fabricating two- (2D) and three-dimensional (3D) microfluidic systems. We demonstrated that the wicking property of the cotton microfluidic channel can be improved by scouring in soda ash (Na2CO3) solution which will remove the natural surface wax and expose the underlying texture of the cellulose fiber. After this treatment, we fabricated narrow hydrophilic channels with hydrophobic barriers made from patterned wax to define the 2D microfluidic devices. The designed pattern is carved on wax-impregnated paper, and subsequently transferred to attached cotton cloth by heat treatment. To further obtain 3D microfluidic devices having multiple layers of pattern, a single layer of wax patterned cloth can be folded along a predefined folding line and subsequently pressed using mechanical force. All the fabrication steps are simple and low cost since no special equipment is required. Diagnostic application of cloth-based devices is shown by the development of simple devices that wick and distribute microvolumes of simulated body fluids along the hydrophilic channels into reaction zones to react with analytical reagents. Colorimetric detection of bovine serum albumin (BSA) in artificial urine is carried out by direct visual observation of bromophenol blue (BPB) colour change in the reaction zones. Finally, we show the flexibility of the novel microfluidic platform by conducting a similar reaction in a bent pinned μCAD.

Graphical abstract: Flexible microfluidic cloth-based analytical devices using a low-cost wax patterning technique

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Aug 2011, accepted on 10 Oct 2011 and first published on 17 Nov 2011


Article type: Paper
DOI: 10.1039/C1LC20764D
Lab Chip, 2012,12, 209-218

  •   Request permissions

    Flexible microfluidic cloth-based analytical devices using a low-cost wax patterning technique

    A. Nilghaz, D. H. B. Wicaksono, D. Gustiono, F. A. Abdul Majid, E. Supriyanto and M. R. Abdul Kadir, Lab Chip, 2012, 12, 209
    DOI: 10.1039/C1LC20764D

Search articles by author

Spotlight

Advertisements