Issue 21, 2012
From the journal:

Journal of Materials Chemistry

Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging†

Dong-Eun Lee,a   Ah Young Kim,ac   Hong Yeol Yoon,ab   Ki Young Choi,ab   Ick Chan Kwon,a   Seo Young Jeong,c   Jae Hyung Park*b  and  Kwangmeyung Kim*a  

* Corresponding authors

a Center for Theragnosis, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea
E-mail: kim@kist.re.kr
Fax: +82 2-958-5909
Tel: +82 2-958-5916

b Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: jhpark1@skku.edu
Fax: +82 31-292-8790
Tel: +82 31-290-7288

c Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, South Korea

Abstract

The amphiphilic hyaluronic acid–5β-cholanic acid (HA–CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.

Graphical abstract: Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

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Article information

DOI
https://doi.org/10.1039/C2JM31406A
Article type
Communication
Submitted
07 Mar 2012
Accepted
10 Apr 2012
First published
11 Apr 2012

J. Mater. Chem., 2012,22, 10444-10447

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Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

D. Lee, A. Y. Kim, H. Y. Yoon, K. Y. Choi, I. C. Kwon, S. Y. Jeong, J. H. Park and K. Kim, J. Mater. Chem., 2012, 22, 10444 DOI: 10.1039/C2JM31406A

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