Lanthanide-doped GdVO4 upconversion nanophosphors with tunable emissions and their applications for biomedical imaging

Abstract

Lanthanide ion doped GdVO₄ upconversion nanoparticles (UCNPs) have been synthesized via a simple hydrothermal process assisted with polyvinylpyrrolidone (PVP). The PVP had great effects on the morphology and luminescent intensity of the final products. Multicolor upconversion emissions such as orange, yellow, green and blue light can be generated by simply changing the codopant compositions or concentrations in these nanoparticles. A thin layer of silica was coated onto the surface of GdVO₄ UCNPs to form a core/shell structure in order to improve their biocompatibility. The applications of the low-toxicity, silica-coated GdVO₄ UCNPs as bio-tag for cell labeling and in vivo animal imaging were reported. In addition, the GdVO₄ nanoparticles showed high contrast T₁-enhancing modality due to the presence of Gd³⁺ ions on the particle surface. Hence, this newly developed multicolor GdVO₄ UCNPs, which can be added into the upconversion nanomaterials family, could be used as a promising nanoprobe for dual-modality with optical bioimaging and magnetic resonance imaging (MRI).