Bifunctional catechol based linkers for modification of TiO2 surfaces

Abstract

Bifunctional linkers for modification of TiO₂ nanoparticles were prepared containing a catechol group for TiO₂ surface attachment and a maleimide and alkyne group for Michael addition and Cu catalysed Huisgen cycloaddition respectively. Peptide and fluorophore functionalised TiO₂ NPs were prepared, different purification methodologies were explored and conjugates were characterized using a range of methods.