Issue 8, 2012
From the journal:

Journal of Analytical Atomic Spectrometry

Trace elements in human follicular fluid: development of a sensitive multielement ICP-MS method for use in biomonitoring studies†

Pamela C. Kruger,*a   Michael S. Bloom,bc   John G. Arnason,ab   Christopher D. Palmer,ab   Victor Y. Fujimotod  and  Patrick J. Parsonsab  

* Corresponding authors

a Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health, P.O. Box 509, Albany, NY 12201-0509, USA
E-mail: pkruger@wadsworth.org
Fax: +1 518 473 7586
Tel: +1 518 402 5508

b Department of Environmental Health Sciences, School of Public Health, The University at Albany, State University of New York, Albany, NY, USA

c Department of Epidemiology and Biostatistics, School of Public Health, The University at Albany, State University of New York, Rensselaer, NY, USA

d Department of Obstetrics, Gynecology, and Reproductive Sciences, The University of California at San Francisco, San Francisco, CA, USA

Abstract

Little information is available in the literature regarding trace element analysis of human follicular fluid. Most peer-reviewed publications offer few details about sample preparation, method development, or method validation. We have attempted to fill this gap in current knowledge by providing comprehensive details of our method development and validation process for the measurement of 24 trace elements (As, Ba, Be, Cd, Co, Cr, Cs, Cu, Hg, Mo, Mg, Mn, Pb, Pt, Rb, Se, Sb, Sn, Sr, Tl, U, V, W, Zn) in follicular fluid. A number of different sample preparation procedures were explored, with a goal of optimizing method detection limits (MDLs), for both quadrupole-inductively coupled plasma-mass spectrometry (Q-ICP-MS) and sector field (SF)-ICP-MS. Human follicular fluid samples (n = 72) were obtained from 64 women undergoing in vitro fertilization (IVF) treatment, and were successfully analyzed for 24 trace elements using SF-ICP-MS.

Graphical abstract: Trace elements in human follicular fluid: development of a sensitive multielement ICP-MS method for use in biomonitoring studies

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Article information

DOI
https://doi.org/10.1039/C2JA30053B
Article type
Paper
Submitted
13 Feb 2012
Accepted
24 Apr 2012
First published
29 May 2012

J. Anal. At. Spectrom., 2012,27, 1245-1253

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Trace elements in human follicular fluid: development of a sensitive multielement ICP-MS method for use in biomonitoring studies

P. C. Kruger, M. S. Bloom, J. G. Arnason, C. D. Palmer, V. Y. Fujimoto and P. J. Parsons, J. Anal. At. Spectrom., 2012, 27, 1245 DOI: 10.1039/C2JA30053B

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