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Issue 1, 2012
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A statistical feature of Hurst exponents of essential genes in bacterial genomes

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Abstract

At present, methods for determining essential genes depend on biochemical experiments. There is therefore a demand for the development of analysis methods and software for identifying essential genes, based on the common features of these genes. In this study, we employed the Hurst exponent as a characteristic parameter and analyzed its distribution among nine bacterial species. We found that most of the significance levels of the Hurst exponents of essential genes were higher than those of the corresponding full-gene-set. Conversely, most of the significance levels of the Hurst exponents of nonessential genes remained unchanged or only increased slightly. Therefore, we propose that this feature represents a restraint for pre- or post-design checking of bacterial essential genes in computer-aided design.

Graphical abstract: A statistical feature of Hurst exponents of essential genes in bacterial genomes

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Article information


Submitted
31 Mar 2011
Accepted
04 Nov 2011
First published
23 Nov 2011

Integr. Biol., 2012,4, 93-98
Article type
Paper

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