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Issue 12, 2012
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Lactic acid as an invaluable bio-based solvent for organic reactions

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Abstract

Lactic acid was used, for the first time, as a bio-based green solvent to promote some organic reactions, such as three-component reactions of styrenes, formaldehyde and an active phenolic compound or N,N-dialkylacetoacetamides, three-component reactions of diethyl acetylenedicarboxylate, anilines and aromatic aldehydes, aniline-catalyzed condensations between salicylaldehydes and diethyl acetylenedicarboxylate, and the synthesis of substituted quinolines through Friedländer annulation between 2′-aminoacetophenone and 1,3-dicarbonyl compounds. In these reactions, lactic acid solvent exhibited many advantages including bio-based origin, superior synthetic efficiency, ease of isolating the product and good recyclability of the reaction medium. The concept of using lactic acid as a green solvent not only enriches the diversity and versatility of bio-based green solvents, but also offers us an effective means for designing environmentally benign synthetic systems.

Graphical abstract: Lactic acid as an invaluable bio-based solvent for organic reactions

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Article information


Submitted
13 Jul 2012
Accepted
19 Oct 2012
First published
22 Oct 2012

Green Chem., 2012,14, 3304-3317
Article type
Paper

Lactic acid as an invaluable bio-based solvent for organic reactions

J. Yang, J. Tan and Y. Gu, Green Chem., 2012, 14, 3304
DOI: 10.1039/C2GC36083G

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