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Issue 11, 2012
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A convenient guide to help select replacement solvents for dichloromethane in chromatography

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Abstract

One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of “drug-like” compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experimentally-derived solvent selection guide to aid chemists in choosing greener solvents for chromatographic purification, with a particular focus on reducing dichloromethane usage.

Graphical abstract: A convenient guide to help select replacement solvents for dichloromethane in chromatography

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Article information


Submitted
10 Jul 2012
Accepted
20 Aug 2012
First published
20 Aug 2012

Green Chem., 2012,14, 3020-3025
Article type
Paper

A convenient guide to help select replacement solvents for dichloromethane in chromatography

J. P. Taygerly, L. M. Miller, A. Yee and E. A. Peterson, Green Chem., 2012, 14, 3020
DOI: 10.1039/C2GC36064K

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