Issue 7, 2012
From the journal:

Green Chemistry

Gold-catalyzed tandem reaction in water: an efficient and convenient synthesis of fused polycyclic indoles†

Enguang Feng,a   Yu Zhou,a   Fei Zhao,a   Xianjie Chen,a   Lei Zhang,a   Hualiang Jianga  and  Hong Liu*a  

* Corresponding authors

a The Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, P.R. China
E-mail: hliu@mail.shcnc.ac.cn

Abstract

This report describes the gold-catalyzed synthesis of fused polycyclic indoles from substituted 2-(1H-indol-1-yl) alkylamines and alkynoic acids in water under microwave irradiation. This protocol proceeds in high atom economy and leads to the generation of two rings, together with the formation of one new C–C bond and two new C–N bonds in a single operation. The advantages of the method include a short reaction time, excellent yield, easy work-up, and the use of microwave irradiation and an environmentally benign solvent.

Graphical abstract: Gold-catalyzed tandem reaction in water: an efficient and convenient synthesis of fused polycyclic indoles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2GC35293A
Article type
Paper
Submitted
28 Feb 2012
Accepted
10 Apr 2012
First published
13 Apr 2012

Green Chem., 2012,14, 1888-1895

Permissions

Request permissions

Gold-catalyzed tandem reaction in water: an efficient and convenient synthesis of fused polycyclic indoles

E. Feng, Y. Zhou, F. Zhao, X. Chen, L. Zhang, H. Jiang and H. Liu, Green Chem., 2012, 14, 1888 DOI: 10.1039/C2GC35293A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements