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Issue 6, 2012
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Effective resolution of 1-phenyl ethanol by Candida antarctica lipase B catalysed acylation with vinyl acetate in protic ionic liquids (PILs)

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Abstract

Herein we report the novel use of essentially anhydrous protic ionic liquids (PILs) as reaction media for performing the smooth kinetic resolution of 1-phenylethanol by Candida antarctica lipase B (CaLB) catalysed acylation with vinyl acetate at 40 °C. Good rates and high enantioselectivities (92–>99%) were observed with suspensions of both the free enzyme and cross-linked enzyme aggregates (CLEAs) of CaLB.

Graphical abstract: Effective resolution of 1-phenyl ethanol by Candida antarctica lipase B catalysed acylation with vinyl acetate in protic ionic liquids (PILs)

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Article information


Submitted
09 Feb 2012
Accepted
20 Mar 2012
First published
21 Mar 2012

Green Chem., 2012,14, 1584-1588
Article type
Communication

Effective resolution of 1-phenyl ethanol by Candida antarctica lipase B catalysed acylation with vinyl acetate in protic ionic liquids (PILs)

A. P. de los Ríos, F. van Rantwijk and R. A. Sheldon, Green Chem., 2012, 14, 1584
DOI: 10.1039/C2GC35196J

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