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Issue 1, 2012
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Catalysis in flow: Au-catalysed alkylation of amines by alcohols

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By using a greater reaction space afforded by a flow reactor, commercially available Au/TiO2 can be used for highly selective direct alkylation of amines by alcohols, without the need for an inert atmosphere or base. A brief survey of substrates includes the alkylation of aromatic, aliphatic and chiral amines by a number of primary and secondary alcohols, in high yield and selectivity. The synthesis of Piribedil, a drug used in the treatment of Parkinson's disease, can be achieved in a single synthetic operation without the need for column chromatography. Mechanistic aspects of the reaction were revealed through modelling of reaction profiles, and the origin of selectivity is attributed to the accessibility of high temperature. The presence of water was found to be crucial for catalyst activity.

Graphical abstract: Catalysis in flow: Au-catalysed alkylation of amines by alcohols

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The article was received on 06 Sep 2011, accepted on 18 Oct 2011 and first published on 24 Nov 2011

Article type: Paper
DOI: 10.1039/C1GC16118K
Citation: Green Chem., 2012,14, 226-232

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    Catalysis in flow: Au-catalysed alkylation of amines by alcohols

    N. Zotova, F. J. Roberts, G. H. Kelsall, A. S. Jessiman, K. Hellgardt and K. K. (. Hii, Green Chem., 2012, 14, 226
    DOI: 10.1039/C1GC16118K

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