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Issue 1, 2012
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Oxidation-hydroxymethylation-reduction: a one-pot three-step biocatalytic synthesis of optically active α-aryl vicinal diols

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Abstract

A one-pot multi-step approach comprising enzymatic oxidation-hydroxymethylation-reduction enables the synthesis of optically active α-aryl vicinal diols with high yields and enantioselectivities. Formaldehyde required for the hydroxymethylation step is enzymatically produced in situ using less hazardous methanol as substrate.

Graphical abstract: Oxidation-hydroxymethylation-reduction: a one-pot three-step biocatalytic synthesis of optically active α-aryl vicinal diols

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Article information


Submitted
01 Sep 2011
Accepted
15 Nov 2011
First published
08 Dec 2011

Green Chem., 2012,14, 94-97
Article type
Communication

Oxidation-hydroxymethylation-reduction: a one-pot three-step biocatalytic synthesis of optically active α-aryl vicinal diols

S. Shanmuganathan, D. Natalia, L. Greiner and P. Domínguez de María, Green Chem., 2012, 14, 94
DOI: 10.1039/C1GC16092C

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