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Volume 161, 2013
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Molecular view on protein sorting into liquid-ordered membrane domains mediated by gangliosides and lipid anchors

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Abstract

We present results from coarse grain molecular dynamics simulations of mixed model membranes consisting of saturated and unsaturated lipids together with cholesterol, in which lipid-anchored membrane proteins are embedded. The membrane proteins studied are the peripherally bound H-Ras, N-Ras, and Hedgehog, and the transmembrane peptides WALP and LAT. We provide a molecular view on how the presence and nature of these lipid anchors affects partitioning of the proteins between liquid-ordered and liquid-disordered domains. In addition, we probed the role of the ganglioside lipid GM1 on the protein sorting, showing formation of GM1-protein nano-domains that act as shuttles between the differently ordered membrane regions.

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Article information


Submitted
27 Apr 2012
Accepted
08 Jun 2012
First published
11 Jun 2012

Faraday Discuss., 2013,161, 347-363
Article type
Paper

Molecular view on protein sorting into liquid-ordered membrane domains mediated by gangliosides and lipid anchors

D. H. de Jong, C. A. Lopez and S. J. Marrink, Faraday Discuss., 2013, 161, 347
DOI: 10.1039/C2FD20086D

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