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Issue 26, 2012
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Yttrium (amidate) complexes for catalytic C–N bond formation. Rapid, room temperature amidation of aldehydes

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Abstract

Yttrium (amidate) precatalysts are highly active for the mild amidation of aldehydes with amines. Reactions occur at room temperature within 5 min in up to 98% isolated yield. These rare-earth systems are effective for this transformation in the absence of supplementary heat, light, base, or oxidants. The reaction proceeds with functionalized amines and/or aldehydes. A comparison of various amidate precatalysts in combination with reaction monitoring suggests that the targeted amide products formed during the reaction promote the formation of alternative catalytically active amidate species in situ.

Graphical abstract: Yttrium (amidate) complexes for catalytic C–N bond formation. Rapid, room temperature amidation of aldehydes

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Article information


Submitted
28 Jan 2012
Accepted
13 Mar 2012
First published
16 Mar 2012

Dalton Trans., 2012,41, 7897-7904
Article type
Paper

Yttrium (amidate) complexes for catalytic C–N bond formation. Rapid, room temperature amidation of aldehydes

J. A. Thomson and L. L. Schafer, Dalton Trans., 2012, 41, 7897
DOI: 10.1039/C2DT30214D

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