Issue 13, 2012
From the journal:

Dalton Transactions

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbeneligands

Diana C. F. Monteiro,a   Roger M. Phillips,b   Benjamin D. Crossley,a   Jake Fieldena  and  Charlotte E. Willans*a  

* Corresponding authors

a School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK
E-mail: c.e.willans@leeds.ac.uk

b Institute of Cancer Therapeutics, University of Bradford, Bradford, UK
E-mail: r.m.phillips@bradford.ac.uk

Abstract

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

Graphical abstract: Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

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Article information

DOI
https://doi.org/10.1039/C2DT12399A
Article type
Paper
Submitted
12 Dec 2011
Accepted
05 Jan 2012
First published
06 Jan 2012

Dalton Trans., 2012,41, 3720-3725

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Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

D. C. F. Monteiro, R. M. Phillips, B. D. Crossley, J. Fielden and C. E. Willans, Dalton Trans., 2012, 41, 3720 DOI: 10.1039/C2DT12399A

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