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Issue 21, 2012
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The therapeutic potential of metal-based antimalarial agents: Implications for the mechanism of action

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Abstract

Despite recent encouraging advances against the disease, malaria remains a major public health problem affecting almost half a billion people and killing almost a million per annum. Due to a short arsenal of efficient antimalarial agents and the frequent appearance of resistance to the drugs in current use, which consequently reduce our means to treat patients, there is a very urgent and continuous need to develop new compounds. This perspective outlines a unique strategy for that purpose through the development of metal-based antimalarial agents. The examples presented here illustrate an attractive alternative to classical drugs.

Graphical abstract: The therapeutic potential of metal-based antimalarial agents: Implications for the mechanism of action

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Article information


Submitted
23 Nov 2011
Accepted
12 Jan 2012
First published
24 Feb 2012

Dalton Trans., 2012,41, 6335-6349
Article type
Perspective

The therapeutic potential of metal-based antimalarial agents: Implications for the mechanism of action

C. Biot, W. Castro, C. Y. Botté and M. Navarro, Dalton Trans., 2012, 41, 6335
DOI: 10.1039/C2DT12247B

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