Issue 21, 2012
From the journal:

Dalton Transactions

Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide†

Isabelle Sasaki,*a   Christian Bijani,a   Sonia Ladeira,ab   Valérie Bourdon,ab   Peter Fallera  and  Christelle Hureau*a  

* Corresponding authors

a CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077 Toulouse, France, France
E-mail: isabelle.sasaki@lcc-toulouse.fr, christelle.hureau@lcc-toulouse.fr
Fax: +33 5 61 55 30 03
Tel: +33 5 61 33 31 20

b Institut de Chimie de Toulouse, FR2599, 118 route de Narbonne, F-31062 Toulouse, France

Abstract

Coordination of a cyclometallated Pt(II) complex (1) to an amyloid-β peptide was probed by NMR and ESI-MS. Furthermore, EPR showed that binding of 1 to the Cu(II)-amyloid-β species resulted in a reshuffling of the Cu(II) coordination sphere, which was absent or lower for the sister non cyclometallated Pt(II) complexes.

Graphical abstract: Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

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Article information

DOI
https://doi.org/10.1039/C2DT12177H
Article type
Communication
Submitted
14 Nov 2011
Accepted
06 Jan 2012
First published
03 Feb 2012

Dalton Trans., 2012,41, 6404-6407

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Interference of a new cyclometallated Pt compound with Cu binding to amyloid-β peptide

I. Sasaki, C. Bijani, S. Ladeira, V. Bourdon, P. Faller and C. Hureau, Dalton Trans., 2012, 41, 6404 DOI: 10.1039/C2DT12177H

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