Jump to main content
Jump to site search

Issue 3, 2012
Previous Article Next Article

Substitution behaviour of novel dinuclear Pt(II) complexes with bio-relevant nucleophiles

Author affiliations

Abstract

The novel dinuclear Pt(II) complexes [{trans-Pt(NH3)2Cl}2(μ-pyrazine)](ClO4)2 (Pt1), [{trans-Pt(NH3)2Cl}2(μ-4,4′-bipyridyl)](ClO4)2·DMF (Pt2), and [{trans-Pt(NH3)2Cl}2(μ-1,2-bis(4-pyridyl)ethane)](ClO4)2 (Pt3), were synthesized. Acid–base titrations, and temperature and concentration dependent kinetic measurements of the reactions with biologically relevant ligands such as thiourea (Tu), glutathione (GSH) and guanosine-5′-monophosphate (5′-GMP) were studied at pH 2.5 and 7.2. The reactions were followed under pseudo-first-order conditions by stopped-flow and UV-vis spectrophotometry. 1H NMR spectroscopy was used to follow the substitution of chloride in the complex [{trans-Pt(NH3)2Cl}2(μ-4,4′-bipyridyl)](ClO4)2·DMF by guanosine-5′-monophosphate (5′-GMP) under second-order conditions. The results indicate that the bridging ligand has an influence on the reactivity of the complexes towards nucleophiles. The order of reactivity of the investigated complexes is Pt1 > Pt2 > Pt3.

Graphical abstract: Substitution behaviour of novel dinuclear Pt(ii) complexes with bio-relevant nucleophiles

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Jul 2011, accepted on 11 Oct 2011 and first published on 08 Nov 2011


Article type: Paper
DOI: 10.1039/C1DT11313E
Citation: Dalton Trans., 2012,41, 876-884
  •   Request permissions

    Substitution behaviour of novel dinuclear Pt(II) complexes with bio-relevant nucleophiles

    T. Soldatović, S. Jovanović, Ž. D. Bugarčić and R. van Eldik, Dalton Trans., 2012, 41, 876
    DOI: 10.1039/C1DT11313E

Search articles by author

Spotlight

Advertisements