Issue 8, 2012
From the journal:

Catalysis Science & Technology

Asymmetric, biocatalytic labeled compound synthesis using transaminases†

Matthew Truppo,*a   Jacob M. Janey,*a   Brendan Grau,a   Krista Morley,a   Scott Pollack,a   Greg Hughesa  and  Ian Daviesa  

* Corresponding authors

a Dept. Process Research, Merck and Co, Inc. Rahway NJ, USA

Abstract

The use of transaminases for the incorporation of deuterium and tritium in chiral amines starting from prochiral ketone precursors has been demonstrated. Efficient labeling was demonstrated using a variety of ketone substrates. Amplification of the labeled product was observed, with tritium incorporation enriched up to 2.8X the statistically expected levels of labeling.

Graphical abstract: Asymmetric, biocatalytic labeled compound synthesis using transaminases

  • This article is part of the themed collection: Biocatalysis
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Article information

DOI
https://doi.org/10.1039/C2CY20110K
Article type
Communication
Submitted
24 Feb 2012
Accepted
19 Mar 2012
First published
20 Mar 2012

Catal. Sci. Technol., 2012,2, 1556-1559

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Asymmetric, biocatalytic labeled compound synthesis using transaminases

M. Truppo, J. M. Janey, B. Grau, K. Morley, S. Pollack, G. Hughes and I. Davies, Catal. Sci. Technol., 2012, 2, 1556 DOI: 10.1039/C2CY20110K

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