Issue 8, 2012
From the journal:

Catalysis Science & Technology

Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium

Manpreet Singh,a   Sawraj Singh,a   Sateesh Deshaboina,a   Hare Krishnen,a   Richard Lloyd,b   Karen Holt-Tiffin,b   Apurba Bhattacharyaa  and  Rakeshwar Bandichhor*a  

* Corresponding authors

a API-R&D, Integrated Product Development, Innovation Plaza, Dr Reddy's Laboratories Ltd., Bachupalli, Qutubullapur, R. R. Dist. 500 072 Andhra Pradesh, India
E-mail: rakeshwarb@drreddys.com
Fax: +91 40 44346164
Tel: +91 40 44346430

b Chirotech Technology Ltd, 410 Cambridge Science Park, Milton Road, Cambridge, Cambridgeshire, UK

Abstract

A whole-cell mediated asymmetric reduction of oxcarbazepine 1 to S-licarbazepine 2, a key intermediate in the synthesis of Eslicarbazepine acetate, was achieved using the yeast strain Pichia methanolica 103660. The reduction was carried out in a biphasic system consisting of (1 : 1) de-ionized water and hexane. This organism catalyzed the reaction to yield the S-enantiomer 2 with excellent conversion (>98%) and enantiomeric excess (ee > 98%) within 24 h of incubation.

Graphical abstract: Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium

  • This article is part of the themed collection: Biocatalysis
About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C2CY00537A
Article type
Paper
Submitted
21 Dec 2011
Accepted
09 Feb 2012
First published
10 Feb 2012

Catal. Sci. Technol., 2012,2, 1602-1605

Permissions

Request permissions

Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium

M. Singh, S. Singh, S. Deshaboina, H. Krishnen, R. Lloyd, K. Holt-Tiffin, A. Bhattacharya and R. Bandichhor, Catal. Sci. Technol., 2012, 2, 1602 DOI: 10.1039/C2CY00537A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements