Issue 21, 2012

Cationic polymers and their therapeutic potential

Abstract

The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.

Graphical abstract: Cationic polymers and their therapeutic potential

Article information

Article type
Critical Review
Submitted
22 Mar 2012
First published
10 Aug 2012

Chem. Soc. Rev., 2012,41, 7147-7194

Cationic polymers and their therapeutic potential

S. K. Samal, M. Dash, S. Van Vlierberghe, D. L. Kaplan, E. Chiellini, C. van Blitterswijk, L. Moroni and P. Dubruel, Chem. Soc. Rev., 2012, 41, 7147 DOI: 10.1039/C2CS35094G

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