Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 11, 2012
Previous Article Next Article

Cyborg cells: functionalisation of living cells with polymers and nanomaterials

Author affiliations

Abstract

Living cells interfaced with a range of polyelectrolyte coatings, magnetic and noble metal nanoparticles, hard mineral shells and other complex nanomaterials can perform functions often completely different from their original specialisation. Such “cyborg cells” are already finding a range of novel applications in areas like whole cell biosensors, bioelectronics, toxicity microscreening, tissue engineering, cell implant protection and bioanalytical chemistry. In this tutorial review, we describe the development of novel methods for functionalisation of cells with polymers and nanoparticles and comment on future advances in this technology in the light of other literature approaches. We review recent studies on the cell viability and function upon direct deposition of nanoparticles, coating with polyelectrolytes, polymer assisted assembly of nanomaterials and hard shells on the cell surface. The cell toxicity issues are considered for many practical applications in terms of possible adverse effects of the deposited polymers, polyelectrolytes and nanoparticles on the cell surface.

Graphical abstract: Cyborg cells: functionalisation of living cells with polymers and nanomaterials

Back to tab navigation

Article information


Submitted
23 Sep 2011
First published
16 Apr 2012

Chem. Soc. Rev., 2012,41, 4189-4206
Article type
Tutorial Review

Cyborg cells: functionalisation of living cells with polymers and nanomaterials

R. F. Fakhrullin, A. I. Zamaleeva, R. T. Minullina, S. A. Konnova and V. N. Paunov, Chem. Soc. Rev., 2012, 41, 4189
DOI: 10.1039/C2CS15264A

Social activity

Search articles by author

Spotlight

Advertisements