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Issue 7, 2012
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Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

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Abstract

Polymeric materials have been extensively developed as a delivery vehicle for nucleic acids over the past two decades. Many previous studies have demonstrated that synthetic delivery vehicles can be highly functionalized by chemical approaches to overcome biological barriers in nucleic acid delivery, similar to viruses. Based on our current knowledge, this tutorial review describes rational strategies in the design of polymeric materials to achieve construction of the versatile vehicles, that is “artificial viruses”, for successful gene therapy, especially focusing on the chemical structures with the minimal adverse effects.

Graphical abstract: Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

  • This article is part of the themed collection: Nanomedicine
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Article information


Submitted
21 Sep 2011
First published
21 Nov 2011

Chem. Soc. Rev., 2012,41, 2562-2574
Article type
Tutorial Review

Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

K. Miyata, N. Nishiyama and K. Kataoka, Chem. Soc. Rev., 2012, 41, 2562
DOI: 10.1039/C1CS15258K

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