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Issue 4, 2012
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Fundamentals of green chemistry: efficiency in reaction design

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In this tutorial review, the fundamental concepts underlying the principles of green and sustainable chemistry - atom and step economy and the E factor - are presented, within the general context of efficiency in organic synthesis. The importance of waste minimisation through the widespread application of catalysis in all its forms – homogeneous, heterogeneous, organocatalysis and biocatalysis – is discussed. These general principles are illustrated with simple practical examples, such as alcohol oxidation and carbonylation and the asymmetric reduction of ketones. The latter reaction is exemplified by a three enzyme process for the production of a key intermediate in the synthesis of the cholesterol lowering agent, atorvastatin. The immobilisation of enzymes as cross-linked enzyme aggregates (CLEAs) as a means of optimizing operational performance is presented. The use of immobilised enzymes in catalytic cascade processes is illustrated with a trienzymatic process for the conversion of benzaldehyde to (S)-mandelic acid using a combi-CLEA containing three enzymes. Finally, the transition from fossil-based chemicals manufacture to a more sustainable biomass-based production is discussed.

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Article information

15 Aug 2011
First published
28 Oct 2011

Chem. Soc. Rev., 2012,41, 1437-1451
Article type
Tutorial Review

Fundamentals of green chemistry: efficiency in reaction design

R. A. Sheldon, Chem. Soc. Rev., 2012, 41, 1437
DOI: 10.1039/C1CS15219J

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