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Issue 4, 2012
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The importance of Green Chemistry in Process Research and Development

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Abstract

Green Chemistry or Sustainable Chemistry is defined by the Environmental Protection Agency as “the design of chemical products that reduce or eliminate the use of hazardous substances” In recent years there is a greater societal expectation that chemists and chemical engineers should produce greener and more sustainable chemical processes and it is likely that this trend will continue to grow over the next few decades. This tutorial review gives information on solvents and solvent selection, basic environmental metrics collection and three industrial case histories. All three case histories involve enzymatic chemistry. Pregabalin (Lyrica®) is produced using a lipase based resolution and is extremely unusual in that all four manufacturing steps to make pregabalin are performed in water. Sitagliptin (Januvia®) uses a transaminase in the final chemical step. Finally a rosuvastatin (Crestor®) intermediate is produced using a deoxy ribose aldolase (DERA) enzyme in which two carboncarbon bonds and two chiral centres are formed in the same process step.

Graphical abstract: The importance of Green Chemistry in Process Research and Development

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Publication details

The article was received on 11 Feb 2011 and first published on 12 May 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15041C
Citation: Chem. Soc. Rev., 2012,41, 1452-1461
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    The importance of Green Chemistry in Process Research and Development

    P. J. Dunn, Chem. Soc. Rev., 2012, 41, 1452
    DOI: 10.1039/C1CS15041C

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