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Issue 11, 2012
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Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

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Abstract

Powder compaction data of three polymorphic Forms I (shearing), II (bending) and III (brittle) of 6-chloro-2,4-dinitroaniline demonstrates a direct relationship among mechanical properties, crystal structure and tableting behaviour, showing the essence of structure based assessment of mechanical properties of crystals, e.g., for identifying more efficient API formulation and manufacture processes.

Graphical abstract: Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

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Publication details

The article was received on 19 Jan 2012, accepted on 13 Mar 2012 and first published on 15 Mar 2012


Article type: Communication
DOI: 10.1039/C2CE25100K
CrystEngComm, 2012,14, 3865-3867

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    Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

    P. P. Bag, M. Chen, C. C. Sun and C. M. Reddy, CrystEngComm, 2012, 14, 3865
    DOI: 10.1039/C2CE25100K

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