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Issue 7, 2012
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Structures and characterization of m-nisoldipine polymorphs

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Abstract

m-Nisoldipine, a dihydropyridine calcium ion antagonist, first synthesized in the School of Pharmaceutical Sciences, Hebei Medical University, exhibits two polymorphs A and B with different colors and morphologies. The single-crystal X-ray structure analysis reveals that polymorph A crystallizes in a monoclinic P21/c space group with a = 9.3045(2) Å, b = 16.5991(5) Å, c = 13.0018(3) Å, β = 91.539(2)° and Z = 4, while B crystallizes in a triclinic space group of P[1 with combining macron] with a = 7.4965(2) Å, b = 11.4692(4) Å, c = 12.3648(5) Å, α = 68.093(2)°, β = 88.655(2)°, γ = 81.853(2)° and Z = 2. The m-nisoldipine molecules are connected through N–H⋯O hydrogen bonds between the carbonyl group and the amine group to form either a wavy chain for A or a linear chain for B. The two polymorphs show distinct physicochemical properties as characterized by IR, Raman, DSC and terahertz pulse spectroscopy. DFT theoretical calculations are also used to simulate the terahertz spectroscopy of the two polymorphs.

Graphical abstract: Structures and characterization of m-nisoldipine polymorphs

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Publication details

The article was received on 13 Oct 2011, accepted on 30 Nov 2011 and first published on 04 Jan 2012


Article type: Paper
DOI: 10.1039/C2CE06359J
CrystEngComm, 2012,14, 2589-2594

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    Structures and characterization of m-nisoldipine polymorphs

    C. Yang, Z. Zhang, Y. Zeng, J. Wang, Y. Wang and B. Ma, CrystEngComm, 2012, 14, 2589
    DOI: 10.1039/C2CE06359J

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