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Issue 99, 2012

One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

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Abstract

Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.

Graphical abstract: One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

Supplementary files

Article information


Submitted
11 Sep 2012
Accepted
29 Oct 2012
First published
30 Oct 2012

Chem. Commun., 2012,48, 12100-12102
Article type
Communication

One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

V. Štrukil, B. Bartolec, T. Portada, I. Đilović, I. Halasz and D. Margetić, Chem. Commun., 2012, 48, 12100 DOI: 10.1039/C2CC36613D

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