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Issue 100, 2012
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Structural basis of single molecular heparin–FX06 interaction revealed by SPM measurements and molecular simulations

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Abstract

Heparin, a functionalized polysaccharide, is observed under a scanning tunneling microscope, which shows atomic scale conformational details. The peptide FX06 is found to bind to five consecutive sugar units of heparin and this interaction is directly revealed by atomic force microscopy and dynamic force spectroscopy measurements. The determined free energy change agrees well with the dynamic calculation result.

Graphical abstract: Structural basis of single molecular heparin–FX06 interaction revealed by SPM measurements and molecular simulations

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Supplementary files

Article information


Submitted
08 Sep 2012
Accepted
01 Nov 2012
First published
02 Nov 2012

Chem. Commun., 2012,48, 12222-12224
Article type
Communication

Structural basis of single molecular heparin–FX06 interaction revealed by SPM measurements and molecular simulations

C. Guo, B. Wang, L. Wang and B. Xu, Chem. Commun., 2012, 48, 12222
DOI: 10.1039/C2CC36546D

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