Issue 93, 2012
From the journal:

Chemical Communications

Mercury–thymine interaction with a chair type G-quadruplex architecture†‡

Nicole M. Smith,a   Samir Amrane,a   Frédéric Rosu,b   Valérie Gabelicab  and  Jean-Louis Mergny*a  

* Corresponding authors

a Univ. Bordeaux, Inserm U869, IECB, 2 rue Robert Escarpit, 33607 Pessac, France
E-mail: jean-louis.mergny@inserm.fr
Fax: +33(0) 5 40 00 30 04
Tel: +33(0) 5 40 00 30 22

b Physical Chemistry and Mass Spectrometry Laboratory, Department of Chemistry, Université de Liège, Belgium

Abstract

The T–Hg–T bond was utilized to cross-link two lateral loops of chair-type G-quadruplex DNA (G4-DNA) structures. Two out of five cross-linking geometries are able to increase the melting temperature and simultaneously reduce the polymorphism of the G4-DNA conformations.

Graphical abstract: Mercury–thymine interaction with a chair type G-quadruplex architecture

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Article information

DOI
https://doi.org/10.1039/C2CC36481F
Article type
Communication
Submitted
05 Sep 2012
Accepted
11 Oct 2012
First published
12 Oct 2012

Chem. Commun., 2012,48, 11464-11466

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Mercury–thymine interaction with a chair type G-quadruplex architecture

N. M. Smith, S. Amrane, F. Rosu, V. Gabelica and J. Mergny, Chem. Commun., 2012, 48, 11464 DOI: 10.1039/C2CC36481F

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