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Issue 92, 2012
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Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

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Abstract

Invasive binding event of PNA into DNA duplex was clearly observed both by atomic force microscope (AFM) imaging and electrophoretic mobility shift assay (EMSA) with the aid of nanomechanical DNA origami devices as ‘single-molecule’ visual probes, showing their potential as universal platform for the analysis of PNA invasion.

Graphical abstract: Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

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Publication details

The article was received on 31 Aug 2012, accepted on 04 Oct 2012 and first published on 05 Oct 2012


Article type: Communication
DOI: 10.1039/C2CC36358E
Chem. Commun., 2012,48, 11361-11363

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    Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

    T. Yamazaki, Y. Aiba, K. Yasuda, Y. Sakai, Y. Yamanaka, A. Kuzuya, Y. Ohya and M. Komiyama, Chem. Commun., 2012, 48, 11361
    DOI: 10.1039/C2CC36358E

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